Cyclophosphamide for injection, usp is a sterile white powder containing cyclophosphamide monohydrate. Set the flow rate to deliver the dose over a minimum of 6 hours for the first dose and over. Cyclophosphamide is often used for 36 months put a disease into remission. Although this shows a high risk of drug interactions in cancer patients.
Each capsule for oral administration contains 25 mg or 50 mg cyclophosphamide anhydrous, usp and the following inactive ingredients. The chemical name for cyclophosphamide is 2bis2chloroethylaminotetrahydro2h1,3,2oxazaphosphorine 2oxide monohydrate. It is also used in selected cases of biopsy proven minimal change nephrotic syndrome in children. Afterwards, a medication that may be less potent with fewer side effects is used to maintain the disease under control. Cyclophosphamide definition of cyclophosphamide by.
Sections or subsections omitted from the full prescribing information are. The treatment of intact cell nuclei may also result in the formation of dnadna crosslinks. Cytoxan cyclophosphamide for injection, usp cytoxan. Cyclophosphamide is soluble in water, saline and ethanol. Concepts searched were dosing of cyclophosphamide in. Cyclophosphamide monohydrate bulk package sigmaaldrich. Effects of ketoconazole on cyclophosphamide metabolism. Pdf 637 kb email article add to my reading list export citation create citation alert. The most common adverse reactions in chemotherapyinduced nausea and vomiting in. Cyclophosphamide is a white crystalline powder with the molecular formula c 7 h 15 cl 2 n 2 o 2 p h 2 o and a molecular weight of 279. Cyclophosphamide is a medicine that kills cancer cells but, as a result, also.
Ns bolus to achieve urine output prior to infusion. Highdose cisplatin and cyclophosphamide with glutathione in the. Throughout this leaflet, cyclophosphamide tablets 50 mg will be. Cyclophosphamide is a synthetic antineoplastic drug chemically related to the nitrogen mustards. Cyclophosphamide is biotransformed principally in the liver to active alkylating metabolites by a mixed function microsomal. The alkylated metabolites of ifosfamide have been shown to interact with dna.
Cyclophosphamide has a molecular formula c 7 h 15 cl 2 n 2 o 2 p h 2 o and a molecular weight of 279. In vitro incubation of dna with activated ifosfamide has produced phosphotriesters. When cyclophosphamide is included in combined cytotoxic regimens, it may be necessary to reduce the dose of cyclophosphamide as well as that of the other drugs. The chemical name for cyclophosphamide is 2 h1,3,2oxazaphosphorin2amine, n,nbis2chloroethyltetrahydro, 2oxide, monohydrate. Cyclophosphamide injectable solution is a prescription medication used to treat many types of cancer. Cyclophosphamide definition is an immunosuppressive and antineoplastic agent c7h15cl2n2o2p used especially in the treatment of lymphomas and some leukemias. Cytoxan cyclophosphamide for injection, usp cytoxan tablets cyclophosphamide tablets, usp description cytoxan cyclophosphamide for injection, usp is a sterile white powder containing cyclophosphamide monohydrate. Sandoz launches first generic version of cyclophosphamide. Pdf cyclophosphamide is an extensively used anticancer and. Incidence and prevention of bladder toxicity from cyclophosphamide.
The chemical name for cyclophosphamide is 2 bis 2chloroethylaminotetrahydro2 h 1,3,2oxazaphosphorine 2oxide monohydrate. Cyclophosphamide for injection, usp, is a chemotherapy agent used to treat certain types of cancer in adults and pediatric patients. Highdose cisplatin and cyclophosphamide with glutathione in the treatment of advanced ovarian cancer. Proposal for the inclusion of mesna world health organization. Cyclophosphamide is a cytotoxic drug or anticancer drug. Find patient medical information for cyclophosphamide oral on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Cyclophosphamide side effects, warnings, dosage, and more. Cytoxan tablets cyclophosphamide tablets, usp are for oral use and contain 25 mg or 50 mg cyclophosphamide anhydrous. A healthcare provider will give you this medication.
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